The effective temperature of mutations
نویسندگان
چکیده
Biological macromolecules experience two seemingly very different types of noise acting on different time scales: i) point mutations corresponding to changes in molecular sequence and ii) thermal fluctuations. Examining the secondary structures of a large number of microRNA precursor sequences and model lattice proteins, we show that the effects of single point mutations are statistically indistinguishable from those of an increase in temperature by a few tens of Kelvins. The existence of such an effective mutational temperature establishes a quantitative connection between robustness to genetic (mutational) and environmental (thermal) perturbations.
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